The Biochemistry Behind Amino Acid Therapy – Part 2

Our first post in this series established the role that transporters play in establishing optimal neurotransmitter synthesis, metabolism and reuptake. Again, based on the work of Marty Hinz, MD, Alvin Stein, MD and Thomas Uncini, MD, the Organic Cation Transporter Type 2 (OCT-2) seems to be the dominant transport system with regards to serotonin and the catecholamines (to learn more, please read The dual-gate lumen model of renal monoamine transport and  APRESS: apical regulatory super system, serotonin,and dopamine interaction). Let’s learn a bit more how and why these gates work and how we can optimize their function using amino acid therapy. (more…)

The Biochemistry Behind Amino Acid Therapy – Part 1

Neurotransmitter dysfunction is the root cause of a whole host of disorders, including depression, anxiety, insomnia, OCD, ADD/ADHD, migraines, trichotillomania, RLS and Parkinson’s disease. Every disorder that has been linked to centrally acting monoamines (i.e., serotonin, dopamine, norepinephrine and/or epinephrine) occurs because inadequate amounts of serotonin, dopamine, norepinephrine and/or epinephrine exists. In order to optimize neurotransmitter function, the total number of these neurotransmitters needs to be increased in the system, the synapse or both. (more…)

Neurotransmitter Testing – How Many Tests Will I Need?

First things first – many labs can measure serotonin and dopamine in the urine (and/or metabolites of these neurotransmitters), but we have only found one lab – DBS Labs – that does so in a manner that allows us to fine tune amino acid dosing. Even though this test is often referred to as a “neurotransmitter test” the proper name for it is Monoamine Transporter Optimization (MTO) or Organic Cation Transporter Assay (OCT Assay). (more…)