histamineTo raise awareness, we are releasing several posts about using amino acid therapy to combat histamine-related disorders and The Anti-Histamine Effect of Amino Acid Therapy –In Depth. Here are a few case studies that highlight the broad utility of this approach.

Case Study #1: Hives

A 27 year old white male with a several week history of urticaria (hives) of unknown etiology had been treated with steroids and antihistamine medications with little effect. The patient was started on 2 pills of D5 Mucuna 40% (L-dopa source) 3x/day and 2 NeuroReplete 2x/day along with 2 CysReplete 3x/day. The rash resolved within 12 hours. One week later the patient stopped the amino acids and the rash returned.

A key takeaway from this case study is that in general, people with collapse of the catecholamine system who are experiencing histamine associated problems require chronic long-term amino acids.

Case Study #2: Asthma

This was an adult female, 50 years old, with a long history of asthma. She was on an inhaler and two other asthma-related medications daily. The day following the start of 2 D5 Mucuna 40% 3x/day with 1 NeuroReplete 2x/day and 2 CysReplete 3x/day the woman reported the asthma was under control and no further inhaler or medications were required.

Case Study #3: Heart burn

Case studies #1 and #2 are H1 histamine related. There are three classes of histamine receptors: H1, H2, and H3. H2 receptors regulate stomach acid secretion. This was a 60 year old white female with a many year history of heart burn. This woman took an H2 blocker (Zantac) and Tums antacids daily. She was started on 2 D5 Mucuna 40% 3x/day and 1 NeuroReplete 2x/day along with 2 CysReplete 3x/day. No results were noted.

One week later, the D5 Mucuna 40% was increased to 4 pills 3x/day. The woman experienced a complete relief of heart burn two days after the dosing change.


Adrenal fatigue, generalized fatigue, and chronic fatigue are all due to inadequate epinephrine (adrenaline) levels being synthesized by the body. It has long been overlooked that allergy induced asthma, urticaria (hives), multiple chemical sensitivities, heart burn, food allergies/sensitivities and severe anaphylactic reactions, etc., are caused by inadequate catecholamine production that is being overwhelmed by the histamine system. Throwing antihistamines and steroids at the problem will NOT return the system to normal. Any through the use of properly balanced amino acid therapy can the epinephrine levels be increased and the system optimized.