NeuroReplete is a balanced amino acid formula that is often used as a foundational part of amino acid therapy. It provides 5-HTP and L-tyrosine along with the cofactors necessary to convert these amino acids into serotonin and the catecholamines (dopamine, norepinephrine and epinephrine), respectively. There are usually very few side effects associated with amino acid therapy; however, nausea can occur in two instances.
NeuroReplete and nausea: Upon startup
When a person first begins amino acid therapy with the use of NeuroReplete and they experience nausea, it is most often a sign that the person’s serotonin levels are exceptionally low. In this case, the nausea will often get progressively worse with each dose of NeuroReplete, and may lead to vomiting.
This is thought to occur because approximately 90% of the body’s store of serotonin is contained in the GI tract. When serotonin levels are very low, the 5-HTP from the NeuroReplete is absorbed and converted into serotonin directly within the GI tract. This causes the smooth muscle of the GI tract to contract, which can be experienced as nausea.
In this instance, the fix is to discontinue the use of the amino acids during the day, and begin taking just one capsule of NeuroReplete before bedtime. The dosage is slowly titrated up every 3-4 days until the full recommended dosing is achieved.
NeuroReplete and nausea: Carbohydrate intolerance
The other instance in which we see people experience nausea with the use of NeuroReplete is in the case of carbohydrate intolerance. This type of nausea is usually experienced sporadically and may be quite intense. If a person tracks their food intake, they will usually find that the nausea is linked to a grain-based carbohydrate (i.e., cracker, bread, cereal, pasta, cookie, etc.) that is eaten within 2 hours of taking the NeuroReplete.
In this instance, it is likely that replenishing the body’s neurotransmitter stores using amino acid therapy has heightened an existing food sensitivity/intolerance, which leads to the sensation of nausea. The fix is to avoid and/or replace the specific grain-based carbohydrate that is causing the issue.
The use of amino acid therapy is extremely effective at addressing the underlying cause of many seemingly unrelated disorders. Side effects are rare with amino acid therapy. If nausea occurs with the use of NeuroReplete, use the suggestions above and speak with your health care provider in order to get the nausea under control.
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Hello,
I am on 30 mg’s of Paxil/day and started taking neuroreplete through my health care provider. Here is what Have done:
1) days 1-2: one capsule with breakfast
2) days 3-4: one capsule with breakfast; one capsule with lunch
3) days 5-6; one capsule with breakfast; one capsule with lunch; one capsule with dinner
4) days 6-7: two capsules with breakfast; one capsule with lunch; one capsule with dinner
5) day 8: Two capsules with breakfast; two capsules with lunch – after this dose I started to feel slightly dizzy and out of sorts. throughout the afternoon I was alternating between some anxiety, depression, and general uneasiness. I called my doctor and he said I need to take CysReplete that we would need to order. I did not take my fifth capsule last night for fear that the symptoms would get worse.
Questions: What should I do? Neuroreplete has really helped my anxiety in the last week, so I would like to stay on it. What is the best way to proceed? If I need to take CysReplete and it needs to be ordered, what should I do in the meantime to minimize/eliminate these symptoms?
Thank you so much for any help you can provide,
Drew
Hi Drew – thanks for contacting us, although I must apologize for my extremely delinquent (!) reply (we were apparently having some website issues and I just now received/reviewed your comment).
You definately want to take CysReplete when working with amino acids. If that does not help, then I would suggest speaking with your health care provider about conducting a DBS test to determine how to properly adjust your amino acid dosing to fit your exact needs. To learn more about DBS testing: https://amino-acid-therapy.com/oct-assay-interpretation/
Good luck!
Dr. Chad